合作客戶/
拜耳公司 |
同濟(jì)大學(xué) |
聯(lián)合大學(xué) |
美國(guó)保潔 |
美國(guó)強(qiáng)生 |
瑞士羅氏 |
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Delta-8 動(dòng)物胃腸道體內(nèi)中藥物的溶解度的測(cè)定——結(jié)論、工具書類！
來源：上海謂載 瀏覽 2068 次 發(fā)布時(shí)間:2021-11-26
結(jié)論
胃腸道pH值和緩沖容量的種間差異是重要的考慮因素，尤其是對(duì)胃腸道給藥的pHresponsive配方和可電離藥物。 因此，兔子和豬的空腸、回腸和近端結(jié)腸具有相對(duì)較高的緩沖容量，而豬遠(yuǎn)端結(jié)腸具有較低的緩沖容量是非常重要的考慮因素。 與人相比，大鼠、兔和豬的近端小腸和升結(jié)腸的液體的滲透壓和表面張力也較高。 胃腸道特征的這些差異導(dǎo)致潑尼松龍?jiān)诖笫篌w內(nèi)的溶解度較高（近端結(jié)腸除外），而潑尼松龍?jiān)谪i和兔體內(nèi)的溶解度與人類相當(dāng)。 因此，如果在大鼠的體液中測(cè)量，中性化合物潑尼松龍的溶解度可能被高估。 另一方面，可電離藥物美沙拉秦在兔和豬體內(nèi)的溶解度在小腸中部高于人，在結(jié)腸中低于人，僅在小腸遠(yuǎn)端與人相當(dāng)。 胃腸道環(huán)境的差異，如pH值、緩沖容量、滲透壓和表面張力，導(dǎo)致藥物溶解度的差異。 在兔子和豬中，美沙拉秦的溶解度在沿胃腸道向下移動(dòng)時(shí)發(fā)生顯著變化，這在很大程度上受管腔液的pH值和滲透壓的影響。
工具書類
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Delta-8 動(dòng)物胃腸道體內(nèi)中藥物的溶解度的測(cè)定——摘要、介紹
Delta-8 動(dòng)物胃腸道體內(nèi)中藥物的溶解度的測(cè)定——材料和方法